About FVH Scoring
FVH (Fluid-Attenuated Inversion Recovery Vascular Hyperintensity) refers to punctate, linear, tubular, or serpentine hyperintensities distributed along the cerebral sulci, cortical surface, or Sylvian fissure on FLAIR (Fluid-Attenuated Inversion Recovery) sequences, appearing hyperintense relative to normal brain tissue. FVH formation is primarily associated with abnormally slowed blood flow velocity.
This tool is based on FLAIR sequence imaging and provides clinicians and researchers with objective, reproducible quantitative FVH assessment through automated segmentation and atlas-weighted scoring.
Analysis Workflow
Automated Segmentation & Weighted Scoring
Based on 3D FLAIR imaging, the nnU-Net v2 framework is employed to achieve automated segmentation of FVH regions. A location-weighted FVH atlas constructed via support vector regression lesion-symptom mapping (SVR-LSM) is then used to compute a continuous, quantitative individualized score (FVHLSM) of FVH burden, providing a non-invasive and convenient alternative tool for perfusion deficit assessment when advanced perfusion imaging is unavailable.
Precise Registration Scoring
The automatically segmented FVH mask is registered to MNI standard space using a combination of affine and nonlinear transformations. The location-weighted atlas constructed via SVR-LSM is then applied to compute the sum of individual voxel β values within each patient's FVH mask, yielding a personalized FVHLSM score.
Outputs include DWI volume (mL), FVH score, and FVHLSM/DWI ratio, providing standardized and reproducible quantitative metrics for clinical research.
Image Analysis
Upload a single 3D FLAIR image and the system will automatically perform segmentation and scoring
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